We measured levels of alpha-tumor necrosis factor (α-TNF) in cerebrospinal fluid and serum samples from 50 drug-free patients with multiple sclerosis, 25 patients with other neurological diseases, 27 patients with non-neurological diseases, and 10 normal subjects. The most elevated levels of α-TNF were found in patients with inflammatory or autoimmune diseases. Comparable serum levels of α-TNF were detected in normal control subjects, patients with multiple sclerosis, and patients with degenerative neurological diseases. In patients with multiple sclerosis, α-TNF levels were also unrelated to time elapsed between the occurrence of clinical exacerbation and the time of sample collection. Only 3 patients with chronic progressive multiple sclerosis had detectable α-TNF in the cerebrospinal fluid. Our data do not support a role for elevated levels of circulating α-TNF in the maintenance of the disease. However, we cannot rule out the possibility that a transient elevation of α-TNF triggers the cellular events leading to demyelination in multiple sclerosis.
Tumor necrosis factor in serum and cerebrospinal fluid of patients with multiple sclerosis / Franciotta DM, Grimaldi LM, Martino GV, Piccolo G, Bergamaschi R, Citterio A, Melzi d'Eril GV.. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - 26:6(1989 Dec), pp. 787-789. [10.1002/ana.410260618]
Tumor necrosis factor in serum and cerebrospinal fluid of patients with multiple sclerosis
G. Melzi d'Eril
1989
Abstract
We measured levels of alpha-tumor necrosis factor (α-TNF) in cerebrospinal fluid and serum samples from 50 drug-free patients with multiple sclerosis, 25 patients with other neurological diseases, 27 patients with non-neurological diseases, and 10 normal subjects. The most elevated levels of α-TNF were found in patients with inflammatory or autoimmune diseases. Comparable serum levels of α-TNF were detected in normal control subjects, patients with multiple sclerosis, and patients with degenerative neurological diseases. In patients with multiple sclerosis, α-TNF levels were also unrelated to time elapsed between the occurrence of clinical exacerbation and the time of sample collection. Only 3 patients with chronic progressive multiple sclerosis had detectable α-TNF in the cerebrospinal fluid. Our data do not support a role for elevated levels of circulating α-TNF in the maintenance of the disease. However, we cannot rule out the possibility that a transient elevation of α-TNF triggers the cellular events leading to demyelination in multiple sclerosis.Pubblicazioni consigliate
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