We compared the binding of human antibodies from patients with neuropathy to the myelin-associated glycoprotein (MAG), to its cross-reactive glycolipid sulfoglucuronyl paragloboside (SGPG), and to sections of peripheral nerve. Titers were correlated with the clinical presentation and results of electrophysiological and pathological studies. Most patients had a predominantly sensory or sensorimotor demyelinating neuropathy and highly elevated antibodies to both MAG and SGPG, but 2 had highly elevated antibodies to MAG alone, and 1 to SGPG alone. Two patients had predominantly motor neuropathy and highly elevated antibodies to SGPG which reacted with MAG by Western blot but not by enzyme-linked immunosorbent assay. One patient had amyotrophic lateral sclerosis and antibodies to SGPG but not to MAG. These studies indicate that the neuropathic syndrome associated with anti-MAG or -SGPG antibodies are more heterogeneous than previously suspected, and that although most of the antibodies react with both MAG and SGPG, some may react with MAG or SGPG alone.
|Titolo:||Anti-MAG and anti-SGPG antibodies in neuropathy|
|Parole Chiave:||autoantibodies; autoimmune disease; myelin-associated glycoprotein (MAG); peripheral neuropathy; sulfoglucuronyl paragloboside (SGPG)|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||mag-1996|
|Digital Object Identifier (DOI):||10.1002/(SICI)1097-4598(199605)19:5<637::AID-MUS12>3.0.CO;2-K|
|Appare nelle tipologie:||01 - Articolo su periodico|