Immune parameters were analyzed in peripheral blood mononuclear cells (PBMC) and cervical mucosa biopsy specimens of human immunodeficiency virus (HIV)-seronegative women sexually exposed to HIV (exposed seronegative [ESN]), HIV-infected women, and healthy women without HIV exposure. HIV was not detected in PBMC or cervical mucosa biopsy specimens of ESN women. However, interleukin (IL)-6, IL-10, IL-12, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha and -beta mRNA were elevated in PBMC and cervical mucosa biopsy specimens of ESN and HIV-infected women; CCR5 and CXCR4 mRNA were augmented in cervical mucosa biopsy specimens, but not in PBMC, of ESN and HIV-infected women; HIV-specific IFN-gamma-secreting cells were detected in vaginal washes of ESN and HIV-infected women; and phenotypic alterations were present in PBMC of ESN women. These results suggest that active HIV infection is not required for T cell activation; immune alterations occur in women in whom HIV infection cannot be detected virologically or clinically.
Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women / M. Biasin, S.L. Caputo, L. Speciale, F. Colombo, L. Racioppi, A. Zagliani, C. Blé, F. Vichi, L. Cianferoni, A.M. Masci, M.L. Villa, P. Ferrante, F. Mazzotta, M. Clerici. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - 182:5(2000), pp. 1365-1374.
|Titolo:||Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women|
BIASIN, MARA (Primo)
CLERICI, MARIO SALVATORE (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
Settore BIO/13 - Biologia Applicata
|Data di pubblicazione:||2000|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1086/315873|
|Appare nelle tipologie:||01 - Articolo su periodico|