Expression of the oestrogen-regulated pS2 protein was investigated on paraffin-embedded sections of primary breast tumours from 200 node-negative patients. Immunoreactivity was observed in 56% of the cases. pS2 expression was inversely correlated with tumour size and proliferative activity, whereas a direct correlation was observed with steroid receptor. 5-year relapse free survival was influenced by tumour size (P = 0.02), oestrogen receptor status (P less than 0.05), and proliferative activity (P less than 0.01). No difference in relapse-free survival was observed between patients subdivided according to pS2 expression alone. However, among patients with oestrogen-receptor-negative tumors, pS2 expression predicted a shorter relapse-free survival.
|Titolo:||Prognostic relevance of pS2 status in association with steroid receptor status and proliferative activity in node-negative breast cancer|
|Parole Chiave:||Humans; Prognosis; Retrospective Studies; Breast Neoplasms; Tumor Suppressor Proteins; Neoplasm Proteins; Receptors, Progesterone; Survival Rate; Proteins; Middle Aged; Female; Immunoenzyme Techniques; Receptors, Estrogen|
|Settore Scientifico Disciplinare:||Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria|
|Data di pubblicazione:||1992|
|Digital Object Identifier (DOI):||10.1016/0959-8049(92)90507-X|
|Appare nelle tipologie:||01 - Articolo su periodico|