Expression of the oestrogen-regulated pS2 protein was investigated on paraffin-embedded sections of primary breast tumours from 200 node-negative patients. Immunoreactivity was observed in 56% of the cases. pS2 expression was inversely correlated with tumour size and proliferative activity, whereas a direct correlation was observed with steroid receptor. 5-year relapse free survival was influenced by tumour size (P = 0.02), oestrogen receptor status (P less than 0.05), and proliferative activity (P less than 0.01). No difference in relapse-free survival was observed between patients subdivided according to pS2 expression alone. However, among patients with oestrogen-receptor-negative tumors, pS2 expression predicted a shorter relapse-free survival.

Prognostic relevance of pS2 status in association with steroid receptor status and proliferative activity in node-negative breast cancer / V. Cappelletti, D. Coradini, E. Scanziani, E. Benini, R. Silvestrini, G. Di Fronzo. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0959-8049. - 28A:8-9(1992), pp. 1315-8-1318.

Prognostic relevance of pS2 status in association with steroid receptor status and proliferative activity in node-negative breast cancer

E. Scanziani;
1992

Abstract

Expression of the oestrogen-regulated pS2 protein was investigated on paraffin-embedded sections of primary breast tumours from 200 node-negative patients. Immunoreactivity was observed in 56% of the cases. pS2 expression was inversely correlated with tumour size and proliferative activity, whereas a direct correlation was observed with steroid receptor. 5-year relapse free survival was influenced by tumour size (P = 0.02), oestrogen receptor status (P less than 0.05), and proliferative activity (P less than 0.01). No difference in relapse-free survival was observed between patients subdivided according to pS2 expression alone. However, among patients with oestrogen-receptor-negative tumors, pS2 expression predicted a shorter relapse-free survival.
Humans; Prognosis; Retrospective Studies; Breast Neoplasms; Tumor Suppressor Proteins; Neoplasm Proteins; Receptors, Progesterone; Survival Rate; Proteins; Middle Aged; Female; Immunoenzyme Techniques; Receptors, Estrogen
Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/185499
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