The effects of a 6-day treatment with 2 mg/day of testosterone, dihydrotestosterone (DHT), 5 alpha-androstan-3 alpha, 17 beta-diol (3 alpha-diol) and 5 alpha-androstan-3 beta, 17 beta-diol (3 beta-diol) on serum prolactin levels have been evaluated in long-term castrated male and female rats. The steroids were administered either in the free alcohol or in the propionated form (mono and dipropionates for the 3 alpha- and 3 beta-diols). Practically no effect of any steroid was evident in the treated male animals. DHT and 3 alpha-diol inhibited prolactin secretion in the female animals, while testosterone and 3 beta-diol remained ineffective. The data suggest a possible role of 5 alpha-reduced compounds, DHT and 3 alpha-diol in the control of prolactin secretion in females.

Effect of 5 alpha-reduced androgens on prolactin secretion / F. Celotti, N. Avogadri, P. Negri-Cesi, M. Motta. - In: ANDROLOGIA. - ISSN 0303-4569. - 14:6(1982), pp. 526-531.

Effect of 5 alpha-reduced androgens on prolactin secretion

F. Celotti
Primo
;
P. Negri-Cesi
Penultimo
;
M. Motta
Ultimo
1982

Abstract

The effects of a 6-day treatment with 2 mg/day of testosterone, dihydrotestosterone (DHT), 5 alpha-androstan-3 alpha, 17 beta-diol (3 alpha-diol) and 5 alpha-androstan-3 beta, 17 beta-diol (3 beta-diol) on serum prolactin levels have been evaluated in long-term castrated male and female rats. The steroids were administered either in the free alcohol or in the propionated form (mono and dipropionates for the 3 alpha- and 3 beta-diols). Practically no effect of any steroid was evident in the treated male animals. DHT and 3 alpha-diol inhibited prolactin secretion in the female animals, while testosterone and 3 beta-diol remained ineffective. The data suggest a possible role of 5 alpha-reduced compounds, DHT and 3 alpha-diol in the control of prolactin secretion in females.
Rats, Inbred Strains; Rats; Prolactin; Animals; Dihydrotestosterone; Androstane-3,17-diol; Male; Female; Androgens
Settore MED/04 - Patologia Generale
Settore BIO/09 - Fisiologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/185474
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