The title ketone, a supposed metabolite of 9-methyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine (MIQ), was prepared and found different on chromatographic comparison from the isolated metabolite M4. However, the pharmacological screening of this compound evidenced, among others, some interesting properties as inhibition of arachidonic acid induced platelet aggregation and protection from both hypobaric and cyanide induced hypoxia in mice. These activities suggest a possible cerebroprotective action to be further investigated.
Synthesis and pharmacological investigation of 9-methyl-1,2,3,4,6,7,12,12b-octahydro-7-oxo-indolo[2,3-a]quinolizine / T. Grandi, F. Sparatore, A. Sparatore. - In: IL FARMACO. - ISSN 0014-827X. - 54:7(1999 Jul 30), pp. 479-485.
Synthesis and pharmacological investigation of 9-methyl-1,2,3,4,6,7,12,12b-octahydro-7-oxo-indolo[2,3-a]quinolizine
A. SparatoreUltimo
1999
Abstract
The title ketone, a supposed metabolite of 9-methyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine (MIQ), was prepared and found different on chromatographic comparison from the isolated metabolite M4. However, the pharmacological screening of this compound evidenced, among others, some interesting properties as inhibition of arachidonic acid induced platelet aggregation and protection from both hypobaric and cyanide induced hypoxia in mice. These activities suggest a possible cerebroprotective action to be further investigated.Pubblicazioni consigliate
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