We report a case of herpetic brainstem encephalitis (HBE) retrospectively diagnosed in an adult patient. Conventional immunovirological studies failed to disclose the etiology of this patient's affection. An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. IEF-O may represent a useful support for in vivo diagnosis of HBE.
Isoelectric focusing herpes simplex virus-gB overlay study in brainstem encephalitis / Martino GV, Grimaldi LM, Franciotta DM, Piccolo G, Brustia R, Minali L, Melzi d'Eril GV.. - In: ACTA NEUROLOGICA SCANDINAVICA. - ISSN 0001-6314. - 82:6(1990 Dec), pp. 364-367.
Titolo: | Isoelectric focusing herpes simplex virus-gB overlay study in brainstem encephalitis |
Autori: | |
Parole Chiave: | brainstem encephalitis; herpes simplex virus type 1; isoelectric focusing antigen overlay; oligoclonal bands |
Settore Scientifico Disciplinare: | Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica |
Data di pubblicazione: | dic-1990 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1600-0404.1990.tb03318.x |
Appare nelle tipologie: | 01 - Articolo su periodico |