Five 1-lupinyl-3R'-6R"-quinoxalin-2(1H)-ones were tested in mice for acute toxicity, explorative activity inhibition, analgesic activity and for antagonism against physostigmine, strychnine and pentylentetrazol (cardiazol). As reference compounds were used chloropromazine, morphine, atropine and diazepam respectively. All tested compounds inhibit the explorative activity and exhibit high analgesic activity. Compound (I) protects completely the animals from physostigmine toxicity, while compound (IV) antagonizes, although only slightly, all the toxicants tested.

[Pharmacologic activity of 1-lupinylquinoxalin-2(1H)-ones, 3,6-disubstituted] / M. Satta, A. Peana, A. Sparatore, M. C. Alamanni. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - 41:9(1986 Sep), pp. 722-728.

[Pharmacologic activity of 1-lupinylquinoxalin-2(1H)-ones, 3,6-disubstituted]

A. Sparatore
Penultimo
;
1986-09

Abstract

Five 1-lupinyl-3R'-6R"-quinoxalin-2(1H)-ones were tested in mice for acute toxicity, explorative activity inhibition, analgesic activity and for antagonism against physostigmine, strychnine and pentylentetrazol (cardiazol). As reference compounds were used chloropromazine, morphine, atropine and diazepam respectively. All tested compounds inhibit the explorative activity and exhibit high analgesic activity. Compound (I) protects completely the animals from physostigmine toxicity, while compound (IV) antagonizes, although only slightly, all the toxicants tested.
Animals; Alkaloids; Lethal Dose 50; Quinoxalines; Exploratory Behavior; Physostigmine; Mice; Analgesics; Male; Female; Anticonvulsants
Settore CHIM/08 - Chimica Farmaceutica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/185401
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