A systematic study of the stereochemistry of oxidation at sulfur catalyzed by cyclohexanone monooxygenase from Acinetobacter using as the substrates numerous alkyl aryl sulfides, dialkyl sulfides and dialkyl disulfides has been carried out. It was found that the structure of the sulfide dramatically influenced the enantioselectivity of the enzyme which yielded sulfoxides with optical purities ranging from 99% ee and R-configuration to 93% ee and S-configuration.
|Titolo:||Effects of substrate structure on the enantioselectivity and stereochemical course of sulfoxidation catalyzed by cyclohexanone monooxygenase|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||1992|
|Digital Object Identifier (DOI):||10.1016/S0957-4166(00)86040-1|
|Appare nelle tipologie:||01 - Articolo su periodico|