Probelm: Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid? Method of study: Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. Results and Conclusion: A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.

Tolerance Signaling Molecules and Pregnancy: IDO, Galectins, and the Renaissance of Regulatory T Cells / P. Terness, M. Kallikourdis, A. G. Betz, G. A. Rabinovich, S. Saito, D. A. Clark. - In: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. - ISSN 1046-7408. - 58:3(2007), pp. 238-254.

Tolerance Signaling Molecules and Pregnancy: IDO, Galectins, and the Renaissance of Regulatory T Cells

M. Kallikourdis
Secondo
;
2007

Abstract

Probelm: Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid? Method of study: Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. Results and Conclusion: A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.
Galectin-1; IDO; Pregnancy immunology; Tolerance; Treg cells
Settore MED/04 - Patologia Generale
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/185189
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