In the brain, the 5 alpha-reductase converting testosterone (T) is present both in neurons and in glial cells, even if it prevails in neurons; the 3 alpha-hydroxysteroid-dehydrogenase (3 alpha-HSD), the enzyme converting dihydrotestosterone (DHT) into 3 alpha-diol, is particularly concentrated in type 1 astrocytes. In glial cells, since the 5 alpha-reductase is activated by a cAMP analogue, PKA seems to be involved in the control of this enzyme, postulating that nervous inputs utilizing cAMP as the second messenger might modify the activity of this enzyme in glial cells. Moreover, the results indicate that, in type 1 astrocytes, both the 5 alpha-reductase and the 3 alpha-HSD are stimulated by the co-culture with neurons and by the addition of neuron-conditioned medium, suggesting that secretory products released by neurons might intervene in the control of glial cell function.
Metabolism of steroids in pure cultures of neurons and glial cells: role of intracellular signalling / R.C. Melcangi, M. Ballabio, V. Magnaghi, F. Celotti. - In: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. - ISSN 0960-0760. - 53:1-6(1995 Jun), pp. 331-336.
|Titolo:||Metabolism of steroids in pure cultures of neurons and glial cells: role of intracellular signalling|
MELCANGI, COSIMO (Primo)
BALLABIO, MARINELLA (Secondo)
MAGNAGHI, VALERIO (Penultimo)
CELOTTI, FABIO MARIA (Ultimo)
|Parole Chiave:||8-Bromo Cyclic Adenosine Monophosphate ; Animals ; Tetradecanoylphorbol Acetate ; Cholestenone 5 alpha-Reductase ; Second Messenger Systems ; Astrocytes ; 3-Hydroxysteroid Dehydrogenases ; Cells, Cultured; Neuroglia ; Neurons ; Dihydrotestosterone ; Oxidoreductases ; Steroids ; Signal Transduction|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
Settore MED/04 - Patologia Generale
Settore BIO/09 - Fisiologia
|Data di pubblicazione:||giu-1995|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0960-0760(95)00071-7|
|Appare nelle tipologie:||01 - Articolo su periodico|