The relationship between benign breast disease and use of oral contraceptives was analyzed in a case-control study conducted in Milan with 288 cases of clinically relevant and histologically confirmed benign breast disease and 285 age-matched controls with a spectrum of acute conditions apparently unrelated to use of oral contraceptives. Compared to the risk for women who had never used oral contraceptives, the relative risk for users was 1.0 (95% confidence interval: 0.6 to 1.5). There was no significant association with duration of use; however, a significantly lower relative risk was found in women using oral contraceptives during the year before breast biopsy (relative risk: 0.4; 95% confidence interval: 0.2 to 0.8). The protection in current users increased with increasing duration of use. In spite of this finding, the overall results of the present study do not support the hypothesis that oral contraceptive use protects against development of histologically confirmed and clinically relevant benign breast disease.
|Titolo:||Oral contraceptives and benign breast disease: a case-control study|
|Parole Chiave:||Contraception Continuation; Contraceptive Agents; Research Methodology; Humans; Physiology; Contraceptives, Oral; Contraceptive Agents, Female; Europe; Developed Countries; Population At Risk; Italy; Southern Europe; Adult; Data Collection; Diseases; Mammary Gland Effects; Family Planning; Adolescent; Time Factors; Contraceptive Methods--beneficial effects; Questionnaires; Fibrocystic Breast Disease; Oral Contraceptives--beneficial effects; Breast Neoplasms; Risk; Contraception; Mediterranean Countries; Middle Aged; Female; Biology|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
Settore MED/40 - Ginecologia e Ostetricia
|Data di pubblicazione:||15-lug-1984|
|Digital Object Identifier (DOI):||10.1016/0002-9378(84)90242-4|
|Appare nelle tipologie:||01 - Articolo su periodico|