We measured some immunological parameters in 20 hospitalized patients with major depression and 20 age- and sex-matched healthy controls. Both enumeration of immune cells, including T-lymphocyte subpopulations, and assay of T-cell function were studied. White blood cells were evaluated with an automated cell counter, T-cell subsets with an immunobead technique, and T-cell function with a phytohemagglutinin-induced proliferation in vitro assay. We found that T-lymphocyte responses to the mitogen were significantly lower in depressed patients than in controls. All the other parameters were normal. These findings suggest that functional but not numerical changes in T-lymphocytes characterize major depressive disorders.

PHA-stimulated cellular immune function and T-lymphocyte subsets in major depressive disorders / Anesi A, Franciotta D, Di Paolo E, Zardini E, Melzi d'Eril GV, Zerbi F.. - In: FUNCTIONAL NEUROLOGY. - ISSN 0393-5264. - 9:1(1994), pp. 17-22.

PHA-stimulated cellular immune function and T-lymphocyte subsets in major depressive disorders

Melzi d'Eril GV;
1994

Abstract

We measured some immunological parameters in 20 hospitalized patients with major depression and 20 age- and sex-matched healthy controls. Both enumeration of immune cells, including T-lymphocyte subpopulations, and assay of T-cell function were studied. White blood cells were evaluated with an automated cell counter, T-cell subsets with an immunobead technique, and T-cell function with a phytohemagglutinin-induced proliferation in vitro assay. We found that T-lymphocyte responses to the mitogen were significantly lower in depressed patients than in controls. All the other parameters were normal. These findings suggest that functional but not numerical changes in T-lymphocytes characterize major depressive disorders.
lymphocyte subsets; major depression; mitogen-induced lymphocyte stimulation; psychoneuroimmunology
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/184982
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