We report the case of a multiple sclerosis (MS) patient without oligoclonal bands (OCB) in three cerebrospinal fluid samples. Restriction fragment length polymorphism analysis of Class 3 genes with radiolabelled specific cDNA probes showed a homozygous deletion of the complement 4A (C4A) genes. Consequent lack of C4A protein can alter the development of humoral immune response probably preventing OCB production. Our observation may suggest a link between a rare immunogenetic pattern and the absence of OCB in MS.

Lack of both spinal fluid oligoclonal bands and complement 4A protein in an MS patient / Franciotta D, Piccolo G, Cuccia M, Bergamaschi R, Zardini E, Melzi d'Eril GV, Dondi E, Cosi V.. - In: ACTA NEUROLOGICA SCANDINAVICA. - ISSN 0001-6314. - 89:1(1994 Jan), pp. 72-74.

Lack of both spinal fluid oligoclonal bands and complement 4A protein in an MS patient

Melzi d'Eril GV;
1994-01

Abstract

We report the case of a multiple sclerosis (MS) patient without oligoclonal bands (OCB) in three cerebrospinal fluid samples. Restriction fragment length polymorphism analysis of Class 3 genes with radiolabelled specific cDNA probes showed a homozygous deletion of the complement 4A (C4A) genes. Consequent lack of C4A protein can alter the development of humoral immune response probably preventing OCB production. Our observation may suggest a link between a rare immunogenetic pattern and the absence of OCB in MS.
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/184966
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