A series of studies was done in order to fully characterize the estrogen receptor (ER) expressed in the hippocampus of adult female rat. The structural identity among the ER mRNAs expressed in the hippocampus, hypothalamus and uterus was established by polymerase chain reaction amplification of the ER cDNA. Subsequently, the ER of the hippocampus was proved to bind DNA and beta-estradiol with the same affinity as the hypothalamic receptor. Finally, it was demonstrated that systemic administration of beta-estradiol determines the nuclear increase of ER levels with a time course which appears to be almost superimposable in the hippocampus and hypothalamus. On the basis of the above-mentioned evidence, it is concluded that the ER expressed in the hippocampus is structurally and functionally indistinguishable from the receptor expressed in the other hormone target tissues.

ESTROGEN-RECEPTOR IN RAT-BRAIN - PRESENCE IN THE HIPPOCAMPAL-FORMATION / E. BETTINI, G. POLLIO, S. SANTAGATI, A. MAGGI. - In: NEUROENDOCRINOLOGY. - ISSN 0028-3835. - 56:4(1992 Oct), pp. 502-508.

ESTROGEN-RECEPTOR IN RAT-BRAIN - PRESENCE IN THE HIPPOCAMPAL-FORMATION

G. POLLIO
Secondo
;
S. SANTAGATI
Penultimo
;
A. MAGGI
Ultimo
1992

Abstract

A series of studies was done in order to fully characterize the estrogen receptor (ER) expressed in the hippocampus of adult female rat. The structural identity among the ER mRNAs expressed in the hippocampus, hypothalamus and uterus was established by polymerase chain reaction amplification of the ER cDNA. Subsequently, the ER of the hippocampus was proved to bind DNA and beta-estradiol with the same affinity as the hypothalamic receptor. Finally, it was demonstrated that systemic administration of beta-estradiol determines the nuclear increase of ER levels with a time course which appears to be almost superimposable in the hippocampus and hypothalamus. On the basis of the above-mentioned evidence, it is concluded that the ER expressed in the hippocampus is structurally and functionally indistinguishable from the receptor expressed in the other hormone target tissues.
CNS; Estrogen receptor; Hippocampus
Settore BIO/14 - Farmacologia
ott-1992
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/184922
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