In a case-control study to evaluate risk factors for endometrial cancer in Italy, use of noncontraceptive estrogens was associated with a moderately increased risk, whereas obesity appeared to be the most important single risk factor related to cancer of the endometrium. This report considers the estrogen and obesity-related relative risks with regard to various prognostic features of tumors (clinical stage, histologic grade, extent of myometrial invasion, lymph node involvement). In both estrogen users and obese women, the increase in relative risk was greater for earlier than for more advanced tumors. These findings, therefore, provide further support for a specific role of both exogenous and endogenous estrogens in endometrial cancer.
|Titolo:||Prognostic features of endometrial cancer in estrogen users and obese women|
|Parole Chiave:||Obesity; Estrogens; Research Methodology; Humans; Physiology; Prognosis; Endocrine System; Aged; Studies; Endometrial Cancer; Hormones; Italy; Cancer; Body Weight; Risk; Neoplasms; Adult; Uterine Neoplasms; Middle Aged; Diseases; Female; Comparative Studies; Biology|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||15-ott-1982|
|Digital Object Identifier (DOI):||10.1016/0002-9378(82)90241-1|
|Appare nelle tipologie:||01 - Articolo su periodico|