In a case-control study to evaluate risk factors for endometrial cancer in Italy, use of noncontraceptive estrogens was associated with a moderately increased risk, whereas obesity appeared to be the most important single risk factor related to cancer of the endometrium. This report considers the estrogen and obesity-related relative risks with regard to various prognostic features of tumors (clinical stage, histologic grade, extent of myometrial invasion, lymph node involvement). In both estrogen users and obese women, the increase in relative risk was greater for earlier than for more advanced tumors. These findings, therefore, provide further support for a specific role of both exogenous and endogenous estrogens in endometrial cancer.

Prognostic features of endometrial cancer in estrogen users and obese women / C. La Vecchia, S. Franceschi, G. Gallus, A. Decarli, E. Colombo, A. Liberati, G. Tognoni. - In: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 0002-9378. - 144:4(1982 Oct 15), pp. 387-390. [10.1016/0002-9378(82)90241-1]

Prognostic features of endometrial cancer in estrogen users and obese women

C. La Vecchia;A. Decarli;
1982

Abstract

In a case-control study to evaluate risk factors for endometrial cancer in Italy, use of noncontraceptive estrogens was associated with a moderately increased risk, whereas obesity appeared to be the most important single risk factor related to cancer of the endometrium. This report considers the estrogen and obesity-related relative risks with regard to various prognostic features of tumors (clinical stage, histologic grade, extent of myometrial invasion, lymph node involvement). In both estrogen users and obese women, the increase in relative risk was greater for earlier than for more advanced tumors. These findings, therefore, provide further support for a specific role of both exogenous and endogenous estrogens in endometrial cancer.
Obesity; Estrogens; Research Methodology; Humans; Physiology; Prognosis; Endocrine System; Aged; Studies; Endometrial Cancer; Hormones; Italy; Cancer; Body Weight; Risk; Neoplasms; Adult; Uterine Neoplasms; Middle Aged; Diseases; Female; Comparative Studies; Biology
Settore MED/01 - Statistica Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/184886
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