We found that serum antibodies present in the serum of patients with motor neuron disease and neuropathy, which were previously shown to react with the oligosaccharide chain of ganglioside GM1(Neu5Ac), can be recognized and titred using the N-glycolylneuraminic acid containing monosialo-gangliotetrahexosylceramide, GM1(Neu5Gc), which is not a component of normal human cells. The antibody-antigen reaction was abolished by immunoabsorption with the free oligosaccharide chain. This result, together with the knowledge that these antibodies recognize several glycoconjugates, supports the conviction that these antibodies are non-specific for a gangliosidic structure.
The anti-oligosaccharide antibodies present in sera from patients with motor neuron disease and neuropathy recognize the N-glycolylneuraminic acid containing gangliotetrahexosyl oligosaccharide / M. Carpo, E. Nobile-Orazio, V. Chigorno, S. Sonnino. - In: GLYCOCONJUGATE JOURNAL. - ISSN 0282-0080. - 12:5(1995 Oct), pp. 729-31-731.
|Titolo:||The anti-oligosaccharide antibodies present in sera from patients with motor neuron disease and neuropathy recognize the N-glycolylneuraminic acid containing gangliotetrahexosyl oligosaccharide|
CARPO, MARINELLA (Primo)
NOBILE-ORAZIO, EDUARDO (Secondo)
SONNINO, SANDRO (Ultimo)
|Parole Chiave:||Antibody Specificity; Animals; Cattle; Demyelinating Diseases; Autoantibodies; Neuraminic Acids; Humans; Oligosaccharides; Glycoconjugates; Gangliosides; Motor Neuron Disease|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
Settore BIO/15 - Biologia Farmaceutica
|Data di pubblicazione:||ott-1995|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/BF00731271|
|Appare nelle tipologie:||01 - Articolo su periodico|