A delta and C fibre function has been investigated in 18 patients affected by neuropathies associated with monoclonal gammopathies. Warm, cold and heat pain thresholds have been determined by means of a Somedic Thermotest, operating on the Peltier principle, in a room at constant temperature. Our results indicate that: 1) there is an involvement of A delta and C fibres in these neuropathies that might be difficult to quantitate only on clinical grounds 2) in IgG and IgA patients, all affected by a subclinical or mild axonal neuropathy, small fibres of both types are always involved 3) in IgM anti-MAG positive severe cases, A delta fibre involvement, suggestive of demyelination is evident, while in one anti-MAG negative patient only C fibres are damaged, probably reflecting a different pathogenetic mechanism.

Small fibre involvement in neuropathy associated with IgG, IgA and IgM monoclonal gammopathy / S. Barbieri, P. Sandroni, E. Nobile-Orazio, A. Cappellari, C. Cavestro, L. Baldini, G. Scarlato. - In: ELECTROMYOGRAPHY AND CLINICAL NEUROPHYSIOLOGY. - ISSN 0301-150X. - 35:1(1995), pp. 39-44-44.

Small fibre involvement in neuropathy associated with IgG, IgA and IgM monoclonal gammopathy

E. Nobile-Orazio;L. Baldini;G. Scarlato
1995

Abstract

A delta and C fibre function has been investigated in 18 patients affected by neuropathies associated with monoclonal gammopathies. Warm, cold and heat pain thresholds have been determined by means of a Somedic Thermotest, operating on the Peltier principle, in a room at constant temperature. Our results indicate that: 1) there is an involvement of A delta and C fibres in these neuropathies that might be difficult to quantitate only on clinical grounds 2) in IgG and IgA patients, all affected by a subclinical or mild axonal neuropathy, small fibres of both types are always involved 3) in IgM anti-MAG positive severe cases, A delta fibre involvement, suggestive of demyelination is evident, while in one anti-MAG negative patient only C fibres are damaged, probably reflecting a different pathogenetic mechanism.
Immunoglobulin A; Humans; Nervous System Diseases; Neural Conduction; Immunoglobulin G; Aged; Paraproteinemias; Middle Aged; Male; Immunoglobulin M; Female; Nerve Fibers
Settore MED/26 - Neurologia
Settore MED/15 - Malattie del Sangue
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/184869
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