The effects of neonatal 6-hydroxydopamine treatment on the brain of control rats and of rats perinatally exposed to morphine were examined. Noradrenaline levels were increased in the pons-medulla, mesencephalon and caudate of 8-week-old control rats lesioned with neonatal 6-hydroxydopamine; perinatal morphine treatment prevented such an increase. In the caudate, there was a loss of dopamine and an increase of serotonin following the neurotoxic lesion; exposure to perinatal morphine prevented the serotonin increase. Brain expression of synapsin I mRNA was particularly abundant in cerebral cortex, hippocampus, dentate gyrus and olfactory bulb. In perinatal morphine-treated rats, the expression of synapsin I mRNA was significantly reduced; interestingly, the neonatal treatment with 6-hydroxydopamine normalized its expression. Therefore, brain-reactive neurochemical changes triggered by 6-hydroxydopamine were suppressed by perinatal morphine exposure whereas the association of morphine exposure and 6-hydroxydopamine lesion promoted the normal mRNA expression of the synaptic marker synapsin I.
Perinatal exposure to morphine: Reactive changes in the brain after 6-hydroxydopamine / A. Gorio, L. Vergani, M. Malosio, E. Lesma, A. Di Giulio. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 303:1-2(1996), pp. 21-26.
|Titolo:||Perinatal exposure to morphine: Reactive changes in the brain after 6-hydroxydopamine|
GORIO, ALFREDO (Primo)
LESMA, ELENA ANNA (Penultimo)
DI GIULIO, ANNA MARIA (Ultimo)
|Parole Chiave:||Neuronal plasticity; Opiate receptor; Pruning effect; Synapsin I|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1996|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0014-2999(96)00054-4|
|Appare nelle tipologie:||01 - Articolo su periodico|