We have previously shown that perinatal exposure to morphine impairs reactive plasticity of serotonin (5-HT) neurons following selective neonatal lesion (Gorio et al., J Neurosci Res 34:462-471, 1993), This study shows that morphine inhibits also that the compensatory sprouting of intact axons after partial denervation, Neonatal 6-OHDA injection causes norepinephrine (NE) depletion in the frontal cortex, which triggers a compensatory increase of dopamine, serotonin (5-HT), and met-enkephalin content correlated by the increased density of tyrosine hydroxylase- and 5-HT-positive axons, In perinatal morphine-treated rats, no compensatory changes are observed after neonatal 6-OHDA depletion of NE in the frontal cortex. (C) 1995 Wiley-Liss, Inc.
Perinatal morphine .2. Changes in cortical plasticity / E. Germani, E. Lesma, S. DeBiasi, A. Di Giulio, A. Bertelli, A. Gorio. - In: JOURNAL OF NEUROSCIENCE RESEARCH. - ISSN 0360-4012. - 42:6(1995), pp. 829-834.
Titolo: | Perinatal morphine .2. Changes in cortical plasticity |
Autori: | LESMA, ELENA ANNA (Secondo) GORIO, ALFREDO (Ultimo) |
Parole Chiave: | 6-OHDA; morphine; neuronal plasticity; opioid receptors |
Settore Scientifico Disciplinare: | Settore BIO/14 - Farmacologia |
Data di pubblicazione: | 1995 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/jnr.490420611 |
Appare nelle tipologie: | 01 - Articolo su periodico |