Three hundred fifty-four evaluable cases of hydatidiform mole diagnosed from 1970 to 1979 in 10 regional hospitals in Lombardy are analyzed in the present report. Twenty-six (7.3%) of the patients developed persistent trophoblastic disease. Younger (less than 20 years) and older (40 years or more) age at diagnosis, a large-for-dates uterus, and ovarian enlargement were associated with an increased risk of developing persistent trophoblastic disease. Twenty-three (9%) cases of persistent trophoblastic disease were observed among 250 women not prophylactically treated, but only in 3 (3%) among 104 who received prophylactic chemotherapy. High-risk groups are defined and the role of prophylactic chemotherapy is discussed.

Management of gestational trophoblastic disease: results of a cooperative study / M. Fasoli, E. Ratti, S. Franceschi, C. La Vecchia, S. Pecorelli, C. Mangioni. - In: OBSTETRICS AND GYNECOLOGY. - ISSN 0029-7844. - 60:2(1982 Aug), pp. 205-209.

Management of gestational trophoblastic disease: results of a cooperative study

C. La Vecchia;
1982-08

Abstract

Three hundred fifty-four evaluable cases of hydatidiform mole diagnosed from 1970 to 1979 in 10 regional hospitals in Lombardy are analyzed in the present report. Twenty-six (7.3%) of the patients developed persistent trophoblastic disease. Younger (less than 20 years) and older (40 years or more) age at diagnosis, a large-for-dates uterus, and ovarian enlargement were associated with an increased risk of developing persistent trophoblastic disease. Twenty-three (9%) cases of persistent trophoblastic disease were observed among 250 women not prophylactically treated, but only in 3 (3%) among 104 who received prophylactic chemotherapy. High-risk groups are defined and the role of prophylactic chemotherapy is discussed.
Ovary; Humans; Interinstitutional Relations; Chorionic Gonadotropin; Italy; Pregnancy; Dinoprost; Adult; Uterine Neoplasms; Methotrexate; Trophoblastic Neoplasms; Dilatation and Curettage; Middle Aged; Prostaglandins F; Adolescent; Obstetrics and Gynecology Department, Hospital; Female
Settore MED/01 - Statistica Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/184813
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