This study examined the sciatic nerve axonal transport of substance P-like immunoreactivity (SPLI) and its basal content in stomach, sciatic nerve and lumbar spinal cord of 8- and 12-week alloxan-diabetic rats, respectively. One group of diabetic rats received acetyl-l-carnitine (ALCAR) throughout the experimental period. Alloxan treatment caused hyperglycemia and reduced body growth. Axonal transport of SPLI was studied by measurement of 24-hour accumulation at a ligature on the sciatic nerve. There was a marked reduction (from 50% to 100% according to the nerve segment examined) of anterograde and retrograde accumulation of SPLI in the constricted nerve of 8-week diabetic rats. In the sciatic nerve of ALCAR-treated diabetic rats, the accumulation of SPLI was comparable to control values. In the sciatic nerve, lumbar spinal cord and stomach of 12-week diabetic rats, there is a significant reduction of SPLI content. ALCAR treatment prevented SPLI loss in these tissues. Sciatic nerves showed the typical sorbitol increase and myo-inositol loss that were significantly counteracted by ALCAR. This study suggests that ALCAR treatment prevents diabetes-induced sensory neuropathy by improving altered metabolic pathways such as polyol activity and myo-inositol synthesis, and by preventing the reduction of synthesis and axonal transport of substance P. (C) 1995 Wiley-Liss, Inc.
DIABETIC NEUROPATHY IN THE RAT .1. ALCAR AUGMENTS THE REDUCED LEVELS AND AXOPLASMIC-TRANSPORT OF SUBSTANCE-P / A. DIGIULIO, E. LESMA, A. GORIO. - In: JOURNAL OF NEUROSCIENCE RESEARCH. - ISSN 0360-4012. - 40:3(1995), pp. 414-419.
|Titolo:||DIABETIC NEUROPATHY IN THE RAT .1. ALCAR AUGMENTS THE REDUCED LEVELS AND AXOPLASMIC-TRANSPORT OF SUBSTANCE-P|
DI GIULIO, ANNA MARIA (Primo)
LESMA, ELENA ANNA (Secondo)
GORIO, ALFREDO (Ultimo)
|Parole Chiave:||acetyl-l-carnitine; axonal transport; diabetic neuropathy; substance P|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1995|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jnr.490400317|
|Appare nelle tipologie:||01 - Articolo su periodico|