This paper reviews some clinically relevant aspects of the epidemiology of ovarian cancer. The items presented and discussed are: (1) incidence and mortality data: they show substantial stability in all Western countries over the last few decades; (2) risk factors: the relationships with child-bearing patterns and other reproductive variables (age at menarche and at menopause; oral contraceptives) appear well established but no risk factor is sufficiently strong to be of practical value in prevention or early diagnosis: (3) long-term survival: in spite of the large number of clinical studies that have claimed 'more effective' treatments, no improvement of long-term survival in the population as a whole has been established. Some discrepancies and drawbacks in published trials are discussed, and a different approach towards clinical studies is suggested.
|Titolo:||The clinical relevance of the epidemiology of ovarian cancer|
|Parole Chiave:||Age Factors; Fertility; Research Methodology; Epidemiologic Methods; Humans; Population Dynamics; Contraceptives, Oral; Contraceptive Agents, Female; Pregnancy History; Oral Contraceptives; Length Of Life; Ovarian Cancer--etiology; Adult; Menarche; Demographic Factors; Diseases; Literature Review; Data Analysis; Time Factors; Parity; Mortality; Ovarian Neoplasms; Cancer; Pregnancy; Risk; Neoplasms; Contraception; Reproductive Period--history; Population; Middle Aged; Reproduction; Menstruation; World Health; Fertility Measurements; Female; Menopause|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||feb-1984|
|Digital Object Identifier (DOI):||10.1016/0277-5379(84)90181-0|
|Appare nelle tipologie:||01 - Articolo su periodico|