IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishThe spindle-shaped cell line TTB was recently isolated from highly vascularized skin lesions of BKV/HIV-1 tat transgenic mice and shown to possess an autocrine loop for hepatocyte growth factor (HGF). We show that fibroblast growth factor-2 (FGF-2) stimulates TTB cell migration and promotes polarization of uPAR at the leading edge of migrating cells. FGF-stimulated TTB cells presented the typical migratory phenotype, with a triangular cell shape and concomitant breakdown of actin stress fibers and smooth muscle-specific actin isoform. FGF-2-stimulated migration was blocked by antibodies against urokinase-type plasminogen activator (uPA) or uPA receptor (uPAR) and by neutralizing anti-HGF antibodies. The latter also inhibited uPAR relocalization at the cell surface of FGF-2-treated TTB cells. This points to a crosstalk between FGF-2 and HGF that might mediate TTB cell migration by modulating the localization of cell surface uPAR.
FGF-2 stimulates migration of Kaposi's sarcoma-like vascular cells by HGF-dependent relocalization of the urokinase receptor / U. Cavallaro, Z. Wu, A. Di Palo, R. Montesano, M. S. Pepper, J. A. Maier, M. R. Soria. - In: THE FASEB JOURNAL. - ISSN 0892-6638. - 12:11(1998 Aug), pp. 1027-1034.
| Titolo: | FGF-2 stimulates migration of Kaposi's sarcoma-like vascular cells by HGF-dependent relocalization of the urokinase receptor |
| Autori: | MAIER, JEANETTE ANNE MARIE (Penultimo) |
| Parole Chiave: | Fibroblast Growth Factor 2; Cytoskeleton; Cell Movement; Sarcoma, Kaposi; Urokinase-Type Plasminogen Activator; Receptors, Urokinase Plasminogen Activator; Receptors, Cell Surface; Hepatocyte Growth Factor; Cell Line |
| Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale |
| Data di pubblicazione: | ago-1998 |
| Rivista: | |
| Tipologia: | Article (author) |
| Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
Copyright © 2021