Fluorescence in situ hybridization with a telomeric probe was used to monitor telomeric renewal following breakage induced by the rare fragile sites FRA10A, FRA12A and FRA16B. Interstitial telomere-like sequences were detected only at the break sites of FRA10A.

Expression of three rare fragile sites: chromosomal truncation, amplification of distal segment and telomeric renewal / N. Villa, L. Dalprà, L. Larizza. - In: CHROMOSOMA. - ISSN 0009-5915. - 106:6(1997 Nov), pp. 400-404.

Expression of three rare fragile sites: chromosomal truncation, amplification of distal segment and telomeric renewal

L. Larizza
Ultimo
1997

Abstract

Fluorescence in situ hybridization with a telomeric probe was used to monitor telomeric renewal following breakage induced by the rare fragile sites FRA10A, FRA12A and FRA16B. Interstitial telomere-like sequences were detected only at the break sites of FRA10A.
Chromosome Deletion; Chromosomes, Human, Pair 16; Telomere; Humans; Infant, Newborn; Chromosome Disorders; Chromosomes, Human, Pair 10; In Situ Hybridization, Fluorescence; Chromosomes, Human, Pair 12; DNA Probes; Chromosome Fragility; Adult; Chromosome Fragile Sites; Chromosome Aberrations; Male; Female
Settore MED/03 - Genetica Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/184506
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