The enantiomeric separation of some muscarinic antagonists bearing a quaternary ammonium group was investigated by using capillary electrophoresis. The effects of alpha-, beta-, gamma-cyclodextrin concentration were studied in an attempt to resolve all the analytes. The use of a coated capillary was found to be essential to improve resolution, efficiency and reproducibility of the separation profile, The sensitivity limit for enantiomeric concentration was as low as 1\% and the response was linear after correction for time migration.
Chiral separation of muscarinic antagonists by capillary zone electrophoresis with cyclodextrin additives / C. Felli, G. Carrea, M. Chiari, M. De Amici, C. De Micheli. - In: JOURNAL OF CHROMATOGRAPHY A. - ISSN 0021-9673. - 741:2(1996), pp. 287-294.
|Titolo:||Chiral separation of muscarinic antagonists by capillary zone electrophoresis with cyclodextrin additives|
DE AMICI, MARCO (Penultimo)
DE MICHELI, CARLO (Ultimo)
|Parole Chiave:||Buffer composition; Cyclodextrins; Enantiomer separation; Muscarinic ligands; Quaternary ammonium compounds|
|Settore Scientifico Disciplinare:||Settore CHIM/08 - Chimica Farmaceutica|
|Data di pubblicazione:||1996|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0021-9673(96)00164-1|
|Appare nelle tipologie:||01 - Articolo su periodico|