The enantiomeric separation of some muscarinic antagonists bearing a quaternary ammonium group was investigated by using capillary electrophoresis. The effects of alpha-, beta-, gamma-cyclodextrin concentration were studied in an attempt to resolve all the analytes. The use of a coated capillary was found to be essential to improve resolution, efficiency and reproducibility of the separation profile, The sensitivity limit for enantiomeric concentration was as low as 1\% and the response was linear after correction for time migration.
Chiral separation of muscarinic antagonists by capillary zone electrophoresis with cyclodextrin additives / C. Felli, G. Carrea, M. Chiari, M. De Amici, C. De Micheli. - In: JOURNAL OF CHROMATOGRAPHY A. - ISSN 0021-9673. - 741:2(1996), pp. 287-294.
Titolo: | Chiral separation of muscarinic antagonists by capillary zone electrophoresis with cyclodextrin additives | |
Autori: | DE AMICI, MARCO (Penultimo) DE MICHELI, CARLO (Ultimo) | |
Parole Chiave: | Buffer composition; Cyclodextrins; Enantiomer separation; Muscarinic ligands; Quaternary ammonium compounds | |
Settore Scientifico Disciplinare: | Settore CHIM/08 - Chimica Farmaceutica | |
Data di pubblicazione: | 1996 | |
Rivista: | ||
Tipologia: | Article (author) | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/0021-9673(96)00164-1 | |
Appare nelle tipologie: | 01 - Articolo su periodico |