A DA-Dapi and AgNOR-negative extranumerary chromosome was identified prenatally in a male fetus and also found in his normal father. Fluorescence in situ hybridization using repetitive DNA probes showed that the minute marker was positive at both ends for beta-satellite sequences, while its centromere was recognized by a 22 alphoid probe. It is concluded that the non-mosaic familial marker represents a 22p isochromosome.

Prenatal diagnosis of an extranumerary i(22p) with normal phenotype / L. Doneda, L. Dalprà, M. G. Tibiletti, L. Larizza. - In: ANNALES DE GENETIQUE. - ISSN 0003-3995. - 36:3(1993), pp. 154-158.

Prenatal diagnosis of an extranumerary i(22p) with normal phenotype

L. Doneda
Primo
;
L. Larizza
Ultimo
1993

Abstract

A DA-Dapi and AgNOR-negative extranumerary chromosome was identified prenatally in a male fetus and also found in his normal father. Fluorescence in situ hybridization using repetitive DNA probes showed that the minute marker was positive at both ends for beta-satellite sequences, while its centromere was recognized by a 22 alphoid probe. It is concluded that the non-mosaic familial marker represents a 22p isochromosome.
chromosome 22; FISH; marker chromosome; repetitive probes
Settore MED/03 - Genetica Medica
Settore BIO/13 - Biologia Applicata
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/184374
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