Genes encoding seven monoclonal antibody-defined cell-surface antigens have been regionally mapped on human chromosome 11, and compared to those of the AL complex defined by polyclonal antibodies using mutational analysis. MIC1, encoding W6/34 antigen, is probably identical to S1, previously mapped to 11pter-p13. MDU1 and MIC8, encoding 4F2 and TRA-1.10 antigens, respectively, are probably identical to S2(a4) and map to 11q13-q22. MIC9, which governs expression of 4D12 and 2E2 antigens, and maps to 11q22-qter, is not related to any of the five AL genes. MIC4 and MIC11, both mapping to 11pter-p13, may have some relationship to S3 and S1, respectively, but identity has not been proven.

Relationships between genes on human chromosome 11 encoding cell-surface antigens / C. Jones, J. Bill, L. Larizza, B. Pym, P. Goodfellow, A. Tunnacliffe. - In: SOMATIC CELL AND MOLECULAR GENETICS. - ISSN 0740-7750. - 10:4(1984 Jul), pp. 423-428.

Relationships between genes on human chromosome 11 encoding cell-surface antigens

L. Larizza;
1984

Abstract

Genes encoding seven monoclonal antibody-defined cell-surface antigens have been regionally mapped on human chromosome 11, and compared to those of the AL complex defined by polyclonal antibodies using mutational analysis. MIC1, encoding W6/34 antigen, is probably identical to S1, previously mapped to 11pter-p13. MDU1 and MIC8, encoding 4F2 and TRA-1.10 antigens, respectively, are probably identical to S2(a4) and map to 11q13-q22. MIC9, which governs expression of 4D12 and 2E2 antigens, and maps to 11q22-qter, is not related to any of the five AL genes. MIC4 and MIC11, both mapping to 11pter-p13, may have some relationship to S3 and S1, respectively, but identity has not been proven.
Glycolipids; Antigens, Surface; Antibodies, Monoclonal; Genes; Humans; Chromosomes, Human, 6-12 and X; Glycoproteins; Mutation; Chromosome Mapping; Molecular Weight
Settore MED/03 - Genetica Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/184344
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