The kinetics of antibody response to the group determinant a and subdeterminants d and y of hepatitis B virus were studied after infection and following immunisation with two recombinant DNA yeast-derived hepatitis B vaccines. The initial antibody response was to the subdeterminant epitopes, whereas anti-a antibody, which provides protection against different subtypes of the virus, was not detected for some weeks or months. The delay in the development of anti-a antibody after active immunisation raises important issues of early protection against infection.
Kinetics of antibody response to hepatitis B virus determinants and to recombinant vaccines in Italy. / A.R. ZANETTI, E. TANZI, L. ROMANO', P. VIGANO', A. CARGNEL, S. HOJVAT, A.J. ZUCKERMAN. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - 32:4(1990), pp. 219-224.
Titolo: | Kinetics of antibody response to hepatitis B virus determinants and to recombinant vaccines in Italy. | |
Autori: | ZANETTI, ALESSANDRO REMO (Primo) TANZI, ELISABETTA (Secondo) | |
Settore Scientifico Disciplinare: | Settore MED/42 - Igiene Generale e Applicata | |
Data di pubblicazione: | 1990 | |
Rivista: | ||
Tipologia: | Article (author) | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/jmv.1890320405 | |
Appare nelle tipologie: | 01 - Articolo su periodico |