The kinetics of antibody response to the group determinant a and subdeterminants d and y of hepatitis B virus were studied after infection and following immunisation with two recombinant DNA yeast-derived hepatitis B vaccines. The initial antibody response was to the subdeterminant epitopes, whereas anti-a antibody, which provides protection against different subtypes of the virus, was not detected for some weeks or months. The delay in the development of anti-a antibody after active immunisation raises important issues of early protection against infection.
|Titolo:||Kinetics of antibody response to hepatitis B virus determinants and to recombinant vaccines in Italy.|
ZANETTI, ALESSANDRO REMO (Primo)
TANZI, ELISABETTA (Secondo)
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
|Data di pubblicazione:||1990|
|Digital Object Identifier (DOI):||10.1002/jmv.1890320405|
|Appare nelle tipologie:||01 - Articolo su periodico|