Erythromycin A was transformed into clarithromycin by the sequence of reactions: selective thexyldimethylsilylation of the 9-oxime, trimethylsilylation of the 2',4 "-hydroxy groups, methylation of the resulting 2',4 "-[O-bis(trimethylsilyl)]-9-[O-(dimethylthexylsilyl)oxime] and acidic regeneration of the protected functionalities.

A new convenient transformation of erythromycin A into clarithromycin / P. Allevi, A. Longo, M. Anastasia. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 7:12(1999), pp. 2749-2752.

A new convenient transformation of erythromycin A into clarithromycin

P. Allevi
Primo
;
M. Anastasia
Ultimo
1999

Abstract

Erythromycin A was transformed into clarithromycin by the sequence of reactions: selective thexyldimethylsilylation of the 9-oxime, trimethylsilylation of the 2',4 "-hydroxy groups, methylation of the resulting 2',4 "-[O-bis(trimethylsilyl)]-9-[O-(dimethylthexylsilyl)oxime] and acidic regeneration of the protected functionalities.
antibiotics ; antibacterials ; clarithromycin ; erythromycin A ; methylation
Settore BIO/10 - Biochimica
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/184244
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