The enantioselective synthesis of the four possible isomers of (E)-4,5-dihydroxydec-2-enal, a cytotoxic product formed in peroxidised liver microsomal lipids, is accomplished via a Sharpless AD reaction alone or associated as appropriate with a regioselective epimerisation of one of the introduced hydroxy groups

Synthesis of all four isomers of (E)-4,5-dihydroxydec-2-enal using osmium-catalysed asymmetric dihydroxylation / P. Allevi, G. Tarocco, A. Longo, M. Anastasia, F. Cajone. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 8:8(1997), pp. 1315-1325. [10.1016/S0957-4166(97)00125-0]

Synthesis of all four isomers of (E)-4,5-dihydroxydec-2-enal using osmium-catalysed asymmetric dihydroxylation

P. Allevi
Primo
;
M. Anastasia
Penultimo
;
1997

Abstract

The enantioselective synthesis of the four possible isomers of (E)-4,5-dihydroxydec-2-enal, a cytotoxic product formed in peroxidised liver microsomal lipids, is accomplished via a Sharpless AD reaction alone or associated as appropriate with a regioselective epimerisation of one of the introduced hydroxy groups
ALPHA,BETA-UNSATURATED ESTERS ; CYCLIC SULFATES ; LIPID PEROXIDATION ; ALDEHYDES ; SHARPLESS AD REACTION
Settore BIO/10 - Biochimica
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/184218
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