Various (R)- and (S)-1-trimethylsilyl-1-alkyn-3-ols, chiral building units useful for the synthesis of biologically active compounds, have been efficiently resolved by enantioselective acetylation mediated by immobilized lipase PS. The resolution is applied to the synthesis of (R)- and (S)-5-octyl-2-(5H)-furanones
Lipase catalysed resolution of (R)- and (S)-1-trimethylsilyl-1-alkyn-3-ols: Useful intermediates for the synthesis of optically active gamma-lactones / P. Allevi, P. Ciuffreda, M. Anastasia. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 8:1(1997), pp. 93-99. [10.1016/S0957-4166(96)00475-2]
Lipase catalysed resolution of (R)- and (S)-1-trimethylsilyl-1-alkyn-3-ols: Useful intermediates for the synthesis of optically active gamma-lactones
P. AlleviPrimo
;P. CiuffredaSecondo
;M. AnastasiaUltimo
1997
Abstract
Various (R)- and (S)-1-trimethylsilyl-1-alkyn-3-ols, chiral building units useful for the synthesis of biologically active compounds, have been efficiently resolved by enantioselective acetylation mediated by immobilized lipase PS. The resolution is applied to the synthesis of (R)- and (S)-5-octyl-2-(5H)-furanones
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