The expression of p53 protein wasinvestigated in eight formalin-fixed, paraffin-embedded conjunctival squamous cell carcinomas offive horses and one cow, dog and cat each by immunohistochemical procedure in order to evaluate proteinoverexpression. Anti-human p53 protein mouse monoclonal antibodies known to be cross-reactive with p53 protein of Ahed the animal species examined were used. Positive p53 nuclear immunostaining was detected BChheedd infive equine, onebovine and one feline cases.Conversely, no p53 immunostaining was found in the only canine case examined. These results demonstrate a frequent p53 overexpression in conjunctival squamous cell carcinoma that could be related to UV- ker induced mutations of the p53 tumor suppressor gene.

p53 protein expression in conjunctival squamous cell carcinomas of domestic animals / G. Sironi, P. Riccaboni, L. Mertel, G. Cammarata, D.E. Brooks. - In: VETERINARY OPHTHALMOLOGY. - ISSN 1463-5216. - 2:4(1999), pp. 227-231. [10.1046/j.1463-5224.1999.00086.x]

p53 protein expression in conjunctival squamous cell carcinomas of domestic animals

G. Sironi
Primo
;
P. Riccaboni
Secondo
;
G. Cammarata
Penultimo
;
1999

Abstract

The expression of p53 protein wasinvestigated in eight formalin-fixed, paraffin-embedded conjunctival squamous cell carcinomas offive horses and one cow, dog and cat each by immunohistochemical procedure in order to evaluate proteinoverexpression. Anti-human p53 protein mouse monoclonal antibodies known to be cross-reactive with p53 protein of Ahed the animal species examined were used. Positive p53 nuclear immunostaining was detected BChheedd infive equine, onebovine and one feline cases.Conversely, no p53 immunostaining was found in the only canine case examined. These results demonstrate a frequent p53 overexpression in conjunctival squamous cell carcinoma that could be related to UV- ker induced mutations of the p53 tumor suppressor gene.
cat, cattle, conjunctival squamous cell carcinoma, dog, horse, p53 protein
Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria
Settore VET/09 - Clinica Chirurgica Veterinaria
Article (author)
File in questo prodotto:
File Dimensione Formato  
p53 protein expression in conjunctival squamous ce.pdf

accesso aperto

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 344.38 kB
Formato Adobe PDF
344.38 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/184201
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 53
  • ???jsp.display-item.citation.isi??? ND
social impact