By means of Golgi staining and gold-toning, we have found an interneuron in the pyramidal cell layer of the hippocampus which forms synapses exclusively on the axon initial segments of pyramidal neurons. An individual initial segment receives up to 30 symmetrical synapses from one axo-axonic cell. Each axo-axonic cell is in synaptic contact with the axon initial segments of several hundred pyramidal neurons. This interneuron is thus ideally situated to synchronise the output of a large population of pyramidal cells and so might be involved in the generation of rhythmic activity and in epileptogenesis.
A new type of specific interneuron in the monkey hippocampus forming synapses exclusively with the axon initial segments of pyramidal cells / P. Somogyi, M. Nunzi, A. Gorio, A. Smith. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 259:1(1983), pp. 137-142. [10.1016/0006-8993(83)91076-4]
A new type of specific interneuron in the monkey hippocampus forming synapses exclusively with the axon initial segments of pyramidal cells
A. GorioPenultimo
;
1983
Abstract
By means of Golgi staining and gold-toning, we have found an interneuron in the pyramidal cell layer of the hippocampus which forms synapses exclusively on the axon initial segments of pyramidal neurons. An individual initial segment receives up to 30 symmetrical synapses from one axo-axonic cell. Each axo-axonic cell is in synaptic contact with the axon initial segments of several hundred pyramidal neurons. This interneuron is thus ideally situated to synchronise the output of a large population of pyramidal cells and so might be involved in the generation of rhythmic activity and in epileptogenesis.
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