In our study, we have measured in vitro proliferation and IL-2 production by human PBL to characterize the interactions between Th cells and accessory cells (AC) involved in responses to either conventional Ag or alloantigens. IL-2 production and proliferative responses to conventional Ag, such as influenza or tetanus, are exclusively dependent on the presence of CD4+ T cells and AC. In contrast, IL-2 and proliferative responses to alloantigen can be mediated by either CD4+ or CD8+ T cells. CD4+ T cells respond to alloantigen using either autologous AC (self-restricted), or allogeneic AC (allo-restricted), whereas CD8+ T cells respond to alloantigen using allogeneic AC only. The understanding of Th cell-AC interactions involved in in vitro allogeneic responses will be important for delineating the Th cell-AC interactions involved in transplantation immunity as well as in clinical disorders characterized by T cell dysfunction such as human immunodeficiency virus infection and systemic lupus erythematosus.
Human in vitro allogeneic responses: demonstration of three pathways of T helper cell activation / C.S. Via, G.C. Tsokos, N.I. Stocks, M. Clerici, G.M. Shearer. - In: JOURNAL OF IMMUNOLOGY. - ISSN 0022-1767. - 144:7(1990), pp. 2524-2528.
|Titolo:||Human in vitro allogeneic responses: demonstration of three pathways of T helper cell activation|
CLERICI, MARIO SALVATORE (Penultimo)
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||1990|
|Appare nelle tipologie:||01 - Articolo su periodico|