By acid induced cyclization of quinolizidin-1-one 4-R-phenylhydrazones several derivatives of 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine (1), bearing a substituent on position 9, were prepared. When R = Cl this reaction gave rise also to a red-orange compound to which the structure (V) of 1-(p-chloro)phenylazo-3,4,6,7,8,9-hexahydroquinolizine was assigned. Substances (1 b)-(1-f) were tested for spontaneous locomotor, muscle relaxant, analgesic, antiinflammatory, diuretic and cardiovascular activities and for influence on pentylentetrazole and sodium pentobarbital actions. Interesting levels of activity were exhibited in several cases.

[Synthesis and pharmacologic activity of 9-R-octahydroindolo[2,3-a]quinolazine] / C. Boido-Canu, V. Boido, F. Sparatore, A. Sparatore, V. Susanna, S. Russo, M. L. Cenicola, E. Marmo. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - 43:10(1988 Oct), pp. 819-837.

[Synthesis and pharmacologic activity of 9-R-octahydroindolo[2,3-a]quinolazine]

A. Sparatore;
1988-10

Abstract

By acid induced cyclization of quinolizidin-1-one 4-R-phenylhydrazones several derivatives of 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine (1), bearing a substituent on position 9, were prepared. When R = Cl this reaction gave rise also to a red-orange compound to which the structure (V) of 1-(p-chloro)phenylazo-3,4,6,7,8,9-hexahydroquinolizine was assigned. Substances (1 b)-(1-f) were tested for spontaneous locomotor, muscle relaxant, analgesic, antiinflammatory, diuretic and cardiovascular activities and for influence on pentylentetrazole and sodium pentobarbital actions. Interesting levels of activity were exhibited in several cases.
Animals; Chemistry; Pentylenetetrazole; Diuretics; Hemodynamics; Mice; Quinolizines; Rats; Indoles; Heart Rate; Pentobarbital; Muscle Relaxants, Central; Chemical Phenomena; Motor Activity; Anti-Inflammatory Agents, Non-Steroidal
Settore CHIM/08 - Chimica Farmaceutica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/183922
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