By acid induced cyclization of quinolizidin-1-one 4-R-phenylhydrazones several derivatives of 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine (1), bearing a substituent on position 9, were prepared. When R = Cl this reaction gave rise also to a red-orange compound to which the structure (V) of 1-(p-chloro)phenylazo-3,4,6,7,8,9-hexahydroquinolizine was assigned. Substances (1 b)-(1-f) were tested for spontaneous locomotor, muscle relaxant, analgesic, antiinflammatory, diuretic and cardiovascular activities and for influence on pentylentetrazole and sodium pentobarbital actions. Interesting levels of activity were exhibited in several cases.
|Titolo:||[Synthesis and pharmacologic activity of 9-R-octahydroindolo[2,3-a]quinolazine]|
|Parole Chiave:||Animals; Chemistry; Pentylenetetrazole; Diuretics; Hemodynamics; Mice; Quinolizines; Rats; Indoles; Heart Rate; Pentobarbital; Muscle Relaxants, Central; Chemical Phenomena; Motor Activity; Anti-Inflammatory Agents, Non-Steroidal|
|Settore Scientifico Disciplinare:||Settore CHIM/08 - Chimica Farmaceutica|
|Data di pubblicazione:||ott-1988|
|Appare nelle tipologie:||01 - Articolo su periodico|