AIM OF THE STUDY: To characterize a case of multifocal microgliomatosis (MCGs) in a dog. MCGs is a CNS tumor of the white matter described in humans and dogs. In the WHO classification MCGs has been included among hystiocytic disorders. However, it’s derivation from the phagocytic microglia has never been fully demonstrated. MATERIALS AND METHODS: A 13 years old, male castrated, Boxer presented with ataxia and behavioural disorders progressing into seizures. Thomograpy revealed two lesions in the left and right cerebral emyspheres. The dog was humanely killed, the brain was removed and examined grossly and microscopically. Immunohistochemistry with anti-canine CD18 and CD45RA and antibodies recognizing vimentin, cytokeratin(AE1/AE3), GFAP, S-100, NSE, CD3 and CD79a was performed. RESULTS: Gross CNS findings were unremarkable. Histology revealed a multifocal mixed proliferative disorder substituting and blending into the white matter of composed of short interlacing and arborizing bundles of atypical spindle cells admixed with gitter cells, mature lymphocytes and granulocytes. No ground substance was present. No angiocentric pattern was evidenced. Spindle cells were vimentin and CD18 positive suggesting a leukocyte origin. All other markers were negative excluding the differential diagnoses such as lymphoma, meningioma, astrocytoma and neuroendocrine tumors. CD18 positive gitter cells and neutrophils were evidenced. Lymphocytes within lesion were mostly CD3 positive mature T cells. CONCLUSION: Our findings suggest tha MCGs is an immunoproliferative disorder resembling the mixed patter of reactive hystiocytoses where the spindle cells bear a phenotype indicative of a leukocyte (non-lymphoid) origin most likely of the CNS microglia.

CNS microgliomatosis: pathological findings in a dog / C. Giudice, P. Roccabianca, D. Stefanello, M. Caniatti, B. Secchiero. ((Intervento presentato al 20. convegno European Society of Veterinary Pathology. 20th Autumn Meeting tenutosi a Grugliasco (TO) nel 2002.

CNS microgliomatosis: pathological findings in a dog

C. Giudice
Primo
;
P. Roccabianca
Secondo
;
D. Stefanello;M. Caniatti
Penultimo
;
B. Secchiero
Ultimo
2002

Abstract

AIM OF THE STUDY: To characterize a case of multifocal microgliomatosis (MCGs) in a dog. MCGs is a CNS tumor of the white matter described in humans and dogs. In the WHO classification MCGs has been included among hystiocytic disorders. However, it’s derivation from the phagocytic microglia has never been fully demonstrated. MATERIALS AND METHODS: A 13 years old, male castrated, Boxer presented with ataxia and behavioural disorders progressing into seizures. Thomograpy revealed two lesions in the left and right cerebral emyspheres. The dog was humanely killed, the brain was removed and examined grossly and microscopically. Immunohistochemistry with anti-canine CD18 and CD45RA and antibodies recognizing vimentin, cytokeratin(AE1/AE3), GFAP, S-100, NSE, CD3 and CD79a was performed. RESULTS: Gross CNS findings were unremarkable. Histology revealed a multifocal mixed proliferative disorder substituting and blending into the white matter of composed of short interlacing and arborizing bundles of atypical spindle cells admixed with gitter cells, mature lymphocytes and granulocytes. No ground substance was present. No angiocentric pattern was evidenced. Spindle cells were vimentin and CD18 positive suggesting a leukocyte origin. All other markers were negative excluding the differential diagnoses such as lymphoma, meningioma, astrocytoma and neuroendocrine tumors. CD18 positive gitter cells and neutrophils were evidenced. Lymphocytes within lesion were mostly CD3 positive mature T cells. CONCLUSION: Our findings suggest tha MCGs is an immunoproliferative disorder resembling the mixed patter of reactive hystiocytoses where the spindle cells bear a phenotype indicative of a leukocyte (non-lymphoid) origin most likely of the CNS microglia.
Dog : microgliomatosis ;
Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria
European Society of Veterinary Pathology
CNS microgliomatosis: pathological findings in a dog / C. Giudice, P. Roccabianca, D. Stefanello, M. Caniatti, B. Secchiero. ((Intervento presentato al 20. convegno European Society of Veterinary Pathology. 20th Autumn Meeting tenutosi a Grugliasco (TO) nel 2002.
Conference Object
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/183920
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact