By acid action on the mixture of homolupinal diethylacetal and arylhydrazines several 3-quinolizidin-1'-yl-5-R-indoles (III a - III e) were prepared. The homolupinal diethylacetal, whose hydrolysis gives rise to the unknown aldehyde, was obtained through the action of lupinylmagnesium chloride on diethylphenylorthoformate. Compounds (III) were subjected to wide pharmacological screening; all of them exhibited calcium blocking, negative cardioinotropic and diuretic activities, while single compounds showed antiinflammatory (III d), anticonvulsant and hypoglycemic (III e) activities.

[Synthesis and pharmacologic activity of 3-quinolizidine-1'-yl-5-R-indoles] / C. Boido-Canu, V. Boido, F. Sparatore, A. Sparatore. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - 43:10(1988 Oct), pp. 801-817.

[Synthesis and pharmacologic activity of 3-quinolizidine-1'-yl-5-R-indoles]

A. Sparatore
Ultimo
1988-10

Abstract

By acid action on the mixture of homolupinal diethylacetal and arylhydrazines several 3-quinolizidin-1'-yl-5-R-indoles (III a - III e) were prepared. The homolupinal diethylacetal, whose hydrolysis gives rise to the unknown aldehyde, was obtained through the action of lupinylmagnesium chloride on diethylphenylorthoformate. Compounds (III) were subjected to wide pharmacological screening; all of them exhibited calcium blocking, negative cardioinotropic and diuretic activities, while single compounds showed antiinflammatory (III d), anticonvulsant and hypoglycemic (III e) activities.
Animals; Chemistry; Cardiotonic Agents; Guinea Pigs; Diuretics; Calcium Channel Blockers; Mice; Quinolizines; Rats; Indoles; Hypoglycemic Agents; Chemical Phenomena; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/183904
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