By acid action on the mixture of homolupinal diethylacetal and arylhydrazines several 3-quinolizidin-1'-yl-5-R-indoles (III a - III e) were prepared. The homolupinal diethylacetal, whose hydrolysis gives rise to the unknown aldehyde, was obtained through the action of lupinylmagnesium chloride on diethylphenylorthoformate. Compounds (III) were subjected to wide pharmacological screening; all of them exhibited calcium blocking, negative cardioinotropic and diuretic activities, while single compounds showed antiinflammatory (III d), anticonvulsant and hypoglycemic (III e) activities.
|Titolo:||[Synthesis and pharmacologic activity of 3-quinolizidine-1'-yl-5-R-indoles]|
SPARATORE, ANNA CONCETTINA (Ultimo)
|Parole Chiave:||Animals; Chemistry; Cardiotonic Agents; Guinea Pigs; Diuretics; Calcium Channel Blockers; Mice; Quinolizines; Rats; Indoles; Hypoglycemic Agents; Chemical Phenomena; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants|
|Settore Scientifico Disciplinare:||Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica|
|Data di pubblicazione:||ott-1988|
|Appare nelle tipologie:||01 - Articolo su periodico|