When methylazoxymethanol acetate is administered to pregnant rats at gestational day 19, the offspring are greatly impaired in the learning of a two-way active avoidance task and these behavioral changes are paralleled by a change in the phosphorylation of the protein B-50/GAP-43 in hippocampus but not in cortex. The expression of the protein is not altered, indicating that the phosphorylation of B-50 is a sensitive marker of alterations in synaptic plasticity associated with impairments of learning abilities in rats.
Selective alteration in B-50/GAP-43 phosphorylation in brain areas of animals characterized by cognitive impairment / M.M.G. Di Luca, F. Merazzi, P.N.E. De Graan, M. Cimino, W. Balduini, W.H. Gispen, F. Cattabeni. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 607:1-2(1993), pp. 329-332.
Selective alteration in B-50/GAP-43 phosphorylation in brain areas of animals characterized by cognitive impairment
M.M.G. Di LucaPrimo
;F. CattabeniUltimo
1993
Abstract
When methylazoxymethanol acetate is administered to pregnant rats at gestational day 19, the offspring are greatly impaired in the learning of a two-way active avoidance task and these behavioral changes are paralleled by a change in the phosphorylation of the protein B-50/GAP-43 in hippocampus but not in cortex. The expression of the protein is not altered, indicating that the phosphorylation of B-50 is a sensitive marker of alterations in synaptic plasticity associated with impairments of learning abilities in rats.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.