When methylazoxymethanol acetate is administered to pregnant rats at gestational day 19, the offspring are greatly impaired in the learning of a two-way active avoidance task and these behavioral changes are paralleled by a change in the phosphorylation of the protein B-50/GAP-43 in hippocampus but not in cortex. The expression of the protein is not altered, indicating that the phosphorylation of B-50 is a sensitive marker of alterations in synaptic plasticity associated with impairments of learning abilities in rats.
Selective alteration in B-50/GAP-43 phosphorylation in brain areas of animals characterized by cognitive impairment / M.M.G. Di Luca, F. Merazzi, P.N.E. De Graan, M. Cimino, W. Balduini, W.H. Gispen, F. Cattabeni. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 607:1-2(1993), pp. 329-332.
Titolo: | Selective alteration in B-50/GAP-43 phosphorylation in brain areas of animals characterized by cognitive impairment |
Autori: | DILUCA, MONICA MARIA GRAZIA (Primo) CATTABENI, FLAMINIO NICOLA (Ultimo) |
Parole Chiave: | B-50/GAP-43; Granule cell; Hippocampus; Learning; Methylazoxymethanol; Protein kinase C |
Settore Scientifico Disciplinare: | Settore BIO/14 - Farmacologia |
Data di pubblicazione: | 1993 |
Rivista: | |
URL: | http://www.ncbi.nlm.nih.gov/pubmed/8481807 |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/0006-8993(93)91525-W |
Appare nelle tipologie: | 01 - Articolo su periodico |