When methylazoxymethanol acetate is administered to pregnant rats at gestational day 19, the offspring are greatly impaired in the learning of a two-way active avoidance task and these behavioral changes are paralleled by a change in the phosphorylation of the protein B-50/GAP-43 in hippocampus but not in cortex. The expression of the protein is not altered, indicating that the phosphorylation of B-50 is a sensitive marker of alterations in synaptic plasticity associated with impairments of learning abilities in rats.

Selective alteration in B-50/GAP-43 phosphorylation in brain areas of animals characterized by cognitive impairment / M.M.G. Di Luca, F. Merazzi, P.N.E. De Graan, M. Cimino, W. Balduini, W.H. Gispen, F. Cattabeni. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 607:1-2(1993), pp. 329-332.

Selective alteration in B-50/GAP-43 phosphorylation in brain areas of animals characterized by cognitive impairment

M.M.G. Di Luca
Primo
;
F. Cattabeni
Ultimo
1993

Abstract

When methylazoxymethanol acetate is administered to pregnant rats at gestational day 19, the offspring are greatly impaired in the learning of a two-way active avoidance task and these behavioral changes are paralleled by a change in the phosphorylation of the protein B-50/GAP-43 in hippocampus but not in cortex. The expression of the protein is not altered, indicating that the phosphorylation of B-50 is a sensitive marker of alterations in synaptic plasticity associated with impairments of learning abilities in rats.
B-50/GAP-43; Granule cell; Hippocampus; Learning; Methylazoxymethanol; Protein kinase C
Settore BIO/14 - Farmacologia
http://www.ncbi.nlm.nih.gov/pubmed/8481807
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/183903
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