New stable leukotriene A4 analog with acetylenic function in positions 14,15 has been synthesized. Conversion of this analog to the corresponding LTC4 derivative and the structural and biological characterization are presented.
Synthesis and biological evaluation of 14, 15-dehydro-LTA4 analog / M. Garcia, T. Durand, J. Rossi, S. Zarini, M. Bolla, G. Folco, P. Wheelan, A. Sala. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 7:2(1997), pp. 105-108.
Synthesis and biological evaluation of 14, 15-dehydro-LTA4 analog
A. SalaUltimo
1997
Abstract
New stable leukotriene A4 analog with acetylenic function in positions 14,15 has been synthesized. Conversion of this analog to the corresponding LTC4 derivative and the structural and biological characterization are presented.
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