Noradrenergic (NA) and serotonergic (5-HT) receptor profiles were compared in the cerebral cortex of young adult (3 months old) and aged (24 months old) male Sprague Dawley rats. Beta and alpha-1 receptors were significantly decreased in 24 month old rats, whereas alpha-2 receptors remained unchanged. 5-HT-2 Postsynaptic receptors and 5-HT high affinity uptake were reduced in aged animals; on the other hand the number of 3H-imipramine (3H-IMI) recognition sites located on serotonin nerve terminals and labelled also by 3H-paroxetine (3H-PAR), were significantly higher in the cerebral cortex of old rats. The ratio 5-hydroxyindoleacetic acid (5-HIAA)/5-HT, an index of serotonin turn-over, increased in some brain areas of senescent rats. There were no age-related changes in the responsiveness of investigated binding sites to subchronic desipramine treatment; the density of beta-noradrenergic and 5-HT-2 serotonergic receptors and that of 3H-IMI binding sites was reduced both in young adult and aged rats.

Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment / N. Brunello, M. Riva, A. C. Rovescalli, R. Galimberti, G. Racagni. - In: PHARMACOLOGY & TOXICOLOGY. - ISSN 0901-9928. - 63:3(1988 Sep), pp. 150-155. [10.1111/j.1600-0773.1988.tb00930.x]

Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment

M. Riva;G. Racagni
1988-09

Abstract

Noradrenergic (NA) and serotonergic (5-HT) receptor profiles were compared in the cerebral cortex of young adult (3 months old) and aged (24 months old) male Sprague Dawley rats. Beta and alpha-1 receptors were significantly decreased in 24 month old rats, whereas alpha-2 receptors remained unchanged. 5-HT-2 Postsynaptic receptors and 5-HT high affinity uptake were reduced in aged animals; on the other hand the number of 3H-imipramine (3H-IMI) recognition sites located on serotonin nerve terminals and labelled also by 3H-paroxetine (3H-PAR), were significantly higher in the cerebral cortex of old rats. The ratio 5-hydroxyindoleacetic acid (5-HIAA)/5-HT, an index of serotonin turn-over, increased in some brain areas of senescent rats. There were no age-related changes in the responsiveness of investigated binding sites to subchronic desipramine treatment; the density of beta-noradrenergic and 5-HT-2 serotonergic receptors and that of 3H-IMI binding sites was reduced both in young adult and aged rats.
Animals; Hydroxyindoleacetic Acid; Aging; Clonidine; Brain; Receptors, Serotonin; Ketanserin; Desipramine; Receptors, Adrenergic; Paroxetine; Serotonin; Rats, Inbred Strains; Rats; Imipramine; Piperidines; Prazosin; Kinetics; Proteins; Dihydroalprenolol; Time Factors; Male
Settore BIO/14 - Farmacologia
PHARMACOLOGY & TOXICOLOGY
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/183570
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