The in vivo turnover rate of acetylcholine was measured in total brain of mice and brain parts of rats after treatment with Napentobarbital, para-chlorophenylalanine and following REM sleep deprivation for 96 hours. Na-pentobarbital decreased the turnover rate of acetylcholine both in total brain of mice and in cortex of rats, but no significant changes were detected in the striatum. Subchronic treatment with parachlorophenylalanine decreased the cortical content of acetylcholine and choline and partially reversed the decrease of turnover rate of acetylcholine elicited by Na-pentobarbital. In REM sleep deprivated rats, the turnover rate of acetylcholine in the cortex was increased.
PENTOBARBITAL AND IN VIVO TURNOVER RATE OF ACETYLCHOLINE IN MOUSE-BRAIN AND IN REGIONS OF RAT BRAIN / M. TRABUCCHI, D. CHENEY, G.A. RACAGNI, E. COSTA. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 7:1(1975), pp. 81-94.
PENTOBARBITAL AND IN VIVO TURNOVER RATE OF ACETYLCHOLINE IN MOUSE-BRAIN AND IN REGIONS OF RAT BRAIN
G.A. RACAGNIPenultimo
;
1975
Abstract
The in vivo turnover rate of acetylcholine was measured in total brain of mice and brain parts of rats after treatment with Napentobarbital, para-chlorophenylalanine and following REM sleep deprivation for 96 hours. Na-pentobarbital decreased the turnover rate of acetylcholine both in total brain of mice and in cortex of rats, but no significant changes were detected in the striatum. Subchronic treatment with parachlorophenylalanine decreased the cortical content of acetylcholine and choline and partially reversed the decrease of turnover rate of acetylcholine elicited by Na-pentobarbital. In REM sleep deprivated rats, the turnover rate of acetylcholine in the cortex was increased.
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