Interleukin (IL)-2, interferon gamma (IFN-gamma; type 1 cytokines), IL-4, and IL-10 (type 2 cytokines), and beta-chemokines (MIP-1alpha and RANTES) production by cord blood lymphocytes (CBL) and peripheral blood lymphocytes (PBL) of newborns was analyzed in a cross-sectional study to examine the maturation of these components of the immune response. Immunophenotyping was performed on the same specimens. Results showed that the CD4/CD8 ratio remains stable, the percentage of natural killer cells decreases, and the number and percentage of B cells increase after birth. Analysis of cytokine production suggested that the production of all cytokines increases gradually and steadily after birth, and that IFN-gamma and IL-10 production is reduced at birth whereas IL-2 and IL-4 production is not. Finally, mitogen-stimulated beta-chemokine production was present at birth and increased slightly but significantly with age. These data indicate that a differential functional maturation of immune response after birth favoring a more precocious development of IL-2 (a type 1 cytokine) is present and should help to analyze the ontogeny of the immune system.
|Titolo:||Differential development of type 1 and type 2 cytokines and beta-chemokines in the ontogeny of healthy newborns|
|Parole Chiave:||Interleukin-10; Chemokines; Interferon-gamma; Humans; Aging; Infant, Newborn; Lymphocytes; Infant; Lymphocyte Count; Cross-Sectional Studies; Interleukin-2; Cells, Cultured; Fetal Blood; Interleukin-4; Cytokines; Macrophage Inflammatory Proteins; Chemokine CCL4; Lymphocyte Subsets; Chemokine CCL3; Immunophenotyping; Chemokine CCL5|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||1999|
|Digital Object Identifier (DOI):||10.1159/000014071|
|Appare nelle tipologie:||01 - Articolo su periodico|