This study evaluates the specificity of some reverse-transcriptase polymerase chain reaction (RT-PCR) assays for the detection of residual tumor cells in breast cancer patients. The following markers have been analysed: carcinoembryonic antigen (CEA), cytokeratins (CK19 and CK20), polymorphic epithelial mucin (MUC-1), epidermal growth factor receptor (EGFR), maspin, and mammaglobin. RT-PCR was employed to detect breast cancer cells in peripheral blood (PB), bone marrow (BM), and stem cell leukoaphereses (PBPC).

Maspin and mammaglobin genes are specific markers for RT-PCR detection of minimal residual disease in patients with breast cancer / P. Corradini, C. Voena, M. Astolfi, S. Delloro, S. Pilotti, G. Arrigoni, M. Bregni, A. Pileri, A. M. Gianni. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 12:12(2001 Dec), pp. 1693-1698. [10.1023/A:1013573108945]

Maspin and mammaglobin genes are specific markers for RT-PCR detection of minimal residual disease in patients with breast cancer

P. Corradini;A.M. Gianni
2001

Abstract

This study evaluates the specificity of some reverse-transcriptase polymerase chain reaction (RT-PCR) assays for the detection of residual tumor cells in breast cancer patients. The following markers have been analysed: carcinoembryonic antigen (CEA), cytokeratins (CK19 and CK20), polymorphic epithelial mucin (MUC-1), epidermal growth factor receptor (EGFR), maspin, and mammaglobin. RT-PCR was employed to detect breast cancer cells in peripheral blood (PB), bone marrow (BM), and stem cell leukoaphereses (PBPC).
Sensitivity and Specificity; Neoplasm, Residual; Carcinoembryonic Antigen; Neoplasm Staging; Receptor, Epidermal Growth Factor; Genes, Tumor Suppressor; Humans; Breast Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Uteroglobin; RNA, Messenger; Keratins; Neoplasm Proteins; Tumor Cells, Cultured; Mammaglobin A; Serpins; Mucin-1; Proteins; Carcinoma, Ductal, Breast; Neoplasms, Ductal, Lobular, and Medullary; Tumor Markers, Biological; Female
Settore MED/06 - Oncologia Medica
Settore MED/15 - Malattie del Sangue
dic-2001
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/183469
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