BAX, a proapoptotic member of the BCL-2 family of proteins, has been detected in Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin's disease (HD), but its clinical significance is unknown. Therefore, we correlated BAX expression with presenting features and clinical outcome in untreated patients with HD.

BAX expression in Hodgkin and Reed-Sternberg cells of Hodgkin's disease: correlation with clinical outcome / G. Z. Rassidakis, L. J. Medeiros, T. J. McDonnell, S. Viviani, V. Bonfante, G. Nadali, T. P. Vassilakopoulos, R. Giardini, M. Chilosi, C. Kittas, A. M. Gianni, G. Bonadonna, G. Pizzolo, G. A. Pangalis, F. Cabanillas, A. H. Sarris. - In: CLINICAL CANCER RESEARCH. - ISSN 1078-0432. - 8:2(2002 Feb), pp. 488-93-493.

BAX expression in Hodgkin and Reed-Sternberg cells of Hodgkin's disease: correlation with clinical outcome

A. M. Gianni;
2002-02

Abstract

BAX, a proapoptotic member of the BCL-2 family of proteins, has been detected in Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin's disease (HD), but its clinical significance is unknown. Therefore, we correlated BAX expression with presenting features and clinical outcome in untreated patients with HD.
bcl-2-Associated X Protein; Humans; Aged; Biopsy; Child; Reed-Sternberg Cells; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins; Adult; Treatment Outcome; Follow-Up Studies; Middle Aged; Adolescent; Time Factors; Hodgkin Disease; Immunohistochemistry; Female; Male
Settore MED/06 - Oncologia Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/183445
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