We studied Leu 7+ cell distribution and natural killer (NK) activity in the peripheral blood of six patients who had peripheral neuropathy and monoclonal IgM protein directed against myelin-associated glycoprotein (anti-MAG IgM). We did not find any difference between patients and control subjects (healthy or polyneuropathic, some with IgM monoclonal paraprotein but without anti-MAG activity). The presence of autologous sera did not interfere with these results. We noted an increase in Leu 11+ cell percentages after pre-incubation of the patient cells with autologous sera but the phenotypes of cells from control subjects did not change after incubation with autologous or patient sera.
NK cells in patients with peripheral neuropathy and IgM monoclonal protein reacting with the myelin-associated glycoprotein (MAG) / O. Della Casa Alberighi, E. Nobile Orazio, P. Bonara, C. Hu, G. Spagnol, L. Radelli, R. Scorza Smeraldi. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 18:3(1988 Jun), pp. 207-16-216.
|Titolo:||NK cells in patients with peripheral neuropathy and IgM monoclonal protein reacting with the myelin-associated glycoprotein (MAG)|
NOBILE ORAZIO, EDUARDO (Secondo)
|Parole Chiave:||Antigens, Differentiation, T-Lymphocyte; Leukocytes, Mononuclear; Myelin Proteins; Humans; Aged; Phenotype; Antibodies, Monoclonal; Myelin-Associated Glycoprotein; Killer Cells, Natural; Peripheral Nervous System Diseases; Middle Aged; Female; Immunoglobulin M; Male|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
Settore MED/09 - Medicina Interna
|Data di pubblicazione:||giu-1988|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0165-5728(88)90098-7|
|Appare nelle tipologie:||01 - Articolo su periodico|