Five patients with neuropathy and IgM M-proteins that reacted with myelin-associated glycoprotein (MAG) were treated for 10 to 20 months with cytostatic agents. In 2 patients, a decrease in serum M-protein and in anti-MAG IgM levels coincided with a progressive improvement of neuropathy. No clinical improvement and no decrease of anti-MAG IgM were observed in the other patients. The close relationship between the decrease of anti-MAG M-proteins and clinical improvement in these patients supports the pathogenetic role of the M-protein in the neuropathy.
Treatment of patients with neuropathy and anti-MAG IgM M-proteins / E. Nobile-Orazio, L. Baldini, S. Barbieri, P. Marmiroli, G. Spagnol, E. Francomano, G. Scarlato. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - 24:1(1988 Jul), pp. 93-7-97.
Treatment of patients with neuropathy and anti-MAG IgM M-proteins
E. Nobile-Orazio;L. Baldini;G. Scarlato
1988
Abstract
Five patients with neuropathy and IgM M-proteins that reacted with myelin-associated glycoprotein (MAG) were treated for 10 to 20 months with cytostatic agents. In 2 patients, a decrease in serum M-protein and in anti-MAG IgM levels coincided with a progressive improvement of neuropathy. No clinical improvement and no decrease of anti-MAG IgM were observed in the other patients. The close relationship between the decrease of anti-MAG M-proteins and clinical improvement in these patients supports the pathogenetic role of the M-protein in the neuropathy.
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