Five patients with neuropathy and IgM M-proteins that reacted with myelin-associated glycoprotein (MAG) were treated for 10 to 20 months with cytostatic agents. In 2 patients, a decrease in serum M-protein and in anti-MAG IgM levels coincided with a progressive improvement of neuropathy. No clinical improvement and no decrease of anti-MAG IgM were observed in the other patients. The close relationship between the decrease of anti-MAG M-proteins and clinical improvement in these patients supports the pathogenetic role of the M-protein in the neuropathy.

Treatment of patients with neuropathy and anti-MAG IgM M-proteins / E. Nobile-Orazio, L. Baldini, S. Barbieri, P. Marmiroli, G. Spagnol, E. Francomano, G. Scarlato. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - 24:1(1988 Jul), pp. 93-7-97.

Treatment of patients with neuropathy and anti-MAG IgM M-proteins

E. Nobile-Orazio;L. Baldini;G. Scarlato
1988

Abstract

Five patients with neuropathy and IgM M-proteins that reacted with myelin-associated glycoprotein (MAG) were treated for 10 to 20 months with cytostatic agents. In 2 patients, a decrease in serum M-protein and in anti-MAG IgM levels coincided with a progressive improvement of neuropathy. No clinical improvement and no decrease of anti-MAG IgM were observed in the other patients. The close relationship between the decrease of anti-MAG M-proteins and clinical improvement in these patients supports the pathogenetic role of the M-protein in the neuropathy.
Prednisone; Blood Proteins; Myelin Proteins; Antineoplastic Agents; Chlorambucil; Humans; Aged; Cyclophosphamide; Myelin-Associated Glycoprotein; Neuromuscular Diseases; Autoantibodies; Peripheral Nervous System Diseases; Middle Aged; Immunoglobulin M; Male; Immunoglobulins
Settore MED/26 - Neurologia
Settore MED/15 - Malattie del Sangue
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/183432
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