Two subsets of tertiary amines (1a-6a) and methiodides (1b-6b) with a structural resemblance to oxotremorine and oxotremorine-M were tested at rabbit vas deferens (M1), guinea pig left atrium (M2), guinea pig ileum and urinary bladder (M3) muscarinic receptor subtypes. The pharmacological profile of the derivatives under study has been discussed by evaluating their potency, affinity and efficacy as well as the regional differences in muscarinic receptor occupancy. (C) 2000 Elsevier Science Inc.
New analogues of oxotremorine and oxotremorine-M - Estimation of their in vitro affinity and efficacy at muscarinic receptor subtypes / E. Barocelli, V. Ballabeni, S. Bertoni, C. Dallanoce, M. De Amici, C. De Micheli, M. Impicciatore. - In: LIFE SCIENCES. - ISSN 0024-3205. - 67:6(2000), pp. 717-723.
Titolo: | New analogues of oxotremorine and oxotremorine-M - Estimation of their in vitro affinity and efficacy at muscarinic receptor subtypes |
Autori: | DE MICHELI, CARLO (Penultimo) |
Parole Chiave: | Functional determination of affinity and efficacy; Muscarinic agonists; Oxotremorine |
Settore Scientifico Disciplinare: | Settore CHIM/08 - Chimica Farmaceutica |
Data di pubblicazione: | 2000 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0024-3205(00)00661-5 |
Appare nelle tipologie: | 01 - Articolo su periodico |