Visual evoked potentials were studied in 11 patients with neuropathy and macroglobulinemia. The P100 latency was increased bilaterally in 5 of the 6 patients whose IgM M-proteins reacted with myelin-associated glycoprotein (MAG) and in 1 of the other patients. In patients whose M-protein bound to MAG, abnormal visual evoked potentials correlated with the presence of the M-protein in the cerebrospinal fluid. Subclinical involvement of the central nervous system is frequent in patients with neuropathy and anti-MAG M-proteins and may be due to the binding of M-proteins to central nervous system myelin.
Visual evoked potentials in patients with neuropathy and macroglobulinemia / S. Barbieri, E. Nobile-Orazio, L. Baldini, Z. Fayoumi, E. Manfredini, G. Scarlato. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - 22:5(1987 Nov), pp. 663-6-666.
Visual evoked potentials in patients with neuropathy and macroglobulinemia
E. Nobile-Orazio;L. Baldini;G. Scarlato
1987
Abstract
Visual evoked potentials were studied in 11 patients with neuropathy and macroglobulinemia. The P100 latency was increased bilaterally in 5 of the 6 patients whose IgM M-proteins reacted with myelin-associated glycoprotein (MAG) and in 1 of the other patients. In patients whose M-protein bound to MAG, abnormal visual evoked potentials correlated with the presence of the M-protein in the cerebrospinal fluid. Subclinical involvement of the central nervous system is frequent in patients with neuropathy and anti-MAG M-proteins and may be due to the binding of M-proteins to central nervous system myelin.Pubblicazioni consigliate
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