Visual evoked potentials were studied in 11 patients with neuropathy and macroglobulinemia. The P100 latency was increased bilaterally in 5 of the 6 patients whose IgM M-proteins reacted with myelin-associated glycoprotein (MAG) and in 1 of the other patients. In patients whose M-protein bound to MAG, abnormal visual evoked potentials correlated with the presence of the M-protein in the cerebrospinal fluid. Subclinical involvement of the central nervous system is frequent in patients with neuropathy and anti-MAG M-proteins and may be due to the binding of M-proteins to central nervous system myelin.
|Titolo:||Visual evoked potentials in patients with neuropathy and macroglobulinemia|
|Parole Chiave:||Waldenstrom Macroglobulinemia; Blood Proteins; Myelin-Associated Glycoprotein; Myelin Proteins; Evoked Potentials, Visual; Peripheral Nervous System Diseases; Humans; Aged; Middle Aged; Male; Female; Immunoglobulins|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
Settore MED/15 - Malattie del Sangue
|Data di pubblicazione:||nov-1987|
|Digital Object Identifier (DOI):||10.1002/ana.410220520|
|Appare nelle tipologie:||01 - Articolo su periodico|