Visual evoked potentials were studied in 11 patients with neuropathy and macroglobulinemia. The P100 latency was increased bilaterally in 5 of the 6 patients whose IgM M-proteins reacted with myelin-associated glycoprotein (MAG) and in 1 of the other patients. In patients whose M-protein bound to MAG, abnormal visual evoked potentials correlated with the presence of the M-protein in the cerebrospinal fluid. Subclinical involvement of the central nervous system is frequent in patients with neuropathy and anti-MAG M-proteins and may be due to the binding of M-proteins to central nervous system myelin.
Visual evoked potentials in patients with neuropathy and macroglobulinemia / S. Barbieri, E. Nobile-Orazio, L. Baldini, Z. Fayoumi, E. Manfredini, G. Scarlato. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - 22:5(1987 Nov), pp. 663-6-666.
Titolo: | Visual evoked potentials in patients with neuropathy and macroglobulinemia |
Autori: | |
Parole Chiave: | Waldenstrom Macroglobulinemia; Blood Proteins; Myelin-Associated Glycoprotein; Myelin Proteins; Evoked Potentials, Visual; Peripheral Nervous System Diseases; Humans; Aged; Middle Aged; Male; Female; Immunoglobulins |
Settore Scientifico Disciplinare: | Settore MED/26 - Neurologia Settore MED/15 - Malattie del Sangue |
Data di pubblicazione: | nov-1987 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/ana.410220520 |
Appare nelle tipologie: | 01 - Articolo su periodico |