Visual evoked potentials were studied in 11 patients with neuropathy and macroglobulinemia. The P100 latency was increased bilaterally in 5 of the 6 patients whose IgM M-proteins reacted with myelin-associated glycoprotein (MAG) and in 1 of the other patients. In patients whose M-protein bound to MAG, abnormal visual evoked potentials correlated with the presence of the M-protein in the cerebrospinal fluid. Subclinical involvement of the central nervous system is frequent in patients with neuropathy and anti-MAG M-proteins and may be due to the binding of M-proteins to central nervous system myelin.

Visual evoked potentials in patients with neuropathy and macroglobulinemia / S. Barbieri, E. Nobile-Orazio, L. Baldini, Z. Fayoumi, E. Manfredini, G. Scarlato. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - 22:5(1987 Nov), pp. 663-6-666.

Visual evoked potentials in patients with neuropathy and macroglobulinemia

E. Nobile-Orazio;L. Baldini;G. Scarlato
1987

Abstract

Visual evoked potentials were studied in 11 patients with neuropathy and macroglobulinemia. The P100 latency was increased bilaterally in 5 of the 6 patients whose IgM M-proteins reacted with myelin-associated glycoprotein (MAG) and in 1 of the other patients. In patients whose M-protein bound to MAG, abnormal visual evoked potentials correlated with the presence of the M-protein in the cerebrospinal fluid. Subclinical involvement of the central nervous system is frequent in patients with neuropathy and anti-MAG M-proteins and may be due to the binding of M-proteins to central nervous system myelin.
Waldenstrom Macroglobulinemia; Blood Proteins; Myelin-Associated Glycoprotein; Myelin Proteins; Evoked Potentials, Visual; Peripheral Nervous System Diseases; Humans; Aged; Middle Aged; Male; Female; Immunoglobulins
Settore MED/26 - Neurologia
Settore MED/15 - Malattie del Sangue
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/183235
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