Peripheral neuropathy was found in 12 (46%) of 26 patients with macroglobulinemia. The neuropathy was subclinical in two. Anti-myelin-associated glycoprotein (MAG) activity was found in six (50%) patients with neuropathy. Sural nerve biopsies showed demyelination and IgM deposits on the myelin sheath. In one patient who had no anti-MAG activity, the serum IgM bound to peripheral myelin by indirect immunofluorescence and to several protein bands in peripheral nerve and other tissues by immunoblot. In the other five patients with neuropathy, we found no binding of M proteins to nerve components, but in three patients there were endoneurial IgM deposits in nerve biopsy. Peripheral neuropathy may be related to the antigen-specificity of M proteins.

Peripheral neuropathy in macroglobulinemia: incidence and antigen-specificity of M proteins / E. Nobile-Orazio, P. Marmiroli, L. Baldini, G. Spagnol, S. Barbieri, M. Moggio, N. Polli, E. Polli, G. Scarlato. - In: NEUROLOGY. - ISSN 0028-3878. - 37:9(1987 Sep), pp. 1506-14-1514.

Peripheral neuropathy in macroglobulinemia: incidence and antigen-specificity of M proteins

E. Nobile-Orazio;L. Baldini;G. Scarlato
1987-09

Abstract

Peripheral neuropathy was found in 12 (46%) of 26 patients with macroglobulinemia. The neuropathy was subclinical in two. Anti-myelin-associated glycoprotein (MAG) activity was found in six (50%) patients with neuropathy. Sural nerve biopsies showed demyelination and IgM deposits on the myelin sheath. In one patient who had no anti-MAG activity, the serum IgM bound to peripheral myelin by indirect immunofluorescence and to several protein bands in peripheral nerve and other tissues by immunoblot. In the other five patients with neuropathy, we found no binding of M proteins to nerve components, but in three patients there were endoneurial IgM deposits in nerve biopsy. Peripheral neuropathy may be related to the antigen-specificity of M proteins.
Blood Proteins; Myelin Proteins; Humans; Aged; Myelin Sheath; Waldenstrom Macroglobulinemia; Myelin-Associated Glycoprotein; Peripheral Nervous System Diseases; Adult; Middle Aged; Female; Immunoglobulin M; Male; Immunoglobulins
Settore MED/26 - Neurologia
Settore MED/15 - Malattie del Sangue
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/183233
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